|
|Section2= |Section6= }} Gamma-linolenic acid or GLA (γ-Linolenic acid), (INN and USAN gamolenic acid) is a fatty acid found primarily in vegetable oils. It is sold as a dietary supplement for a variety of human health problems, although there is little or no evidence of its effectiveness.〔(Cochrane Collaboration meta-analysis: Oral evening primrose oil and borage oil for eczema ). Conclusion: lack effect on eczema.〕〔(Cochrane Collaboration meta-analysis: Herbal therapy for treating rheumatoid arthritis ). Conclusion: moderate evidence that oils containing GLA afford some benefit in relieving symptoms for RA. Many trials of herbal therapies are hampered by research design flaws and inadequate reporting.〕〔( Cochrane Collaboration meta-analysis: Polyunsaturated fatty acid supplementation for schizophrenia ). Conclusion: Some studies show some improvement, but not statistically significant. Trials were small and short, most of the data they reported were not usable, and half of the trials were funded by the group supplying the trial medication.〕 However, when acting on GLA, 5-lipoxygenase produces no leukotrienes and the conversion by the enzyme of arachidonic acid to leukotrienes is inhibited. ==Chemistry== GLA is categorized as an ''n''−6 (also called ω−6 or omega-6) fatty acid, meaning that the first double bond on the methyl end (designated with ''n'' or ω) is the sixth bond. In physiological literature, GLA is designated as 18:3 (''n''−6). GLA is a carboxylic acid with an 18-carbon chain and three ''cis'' double bonds. It is an isomer of α-linolenic acid, which is a polyunsaturated n−3 (omega-3) fatty acid, found in rapeseed canola oil, soy beans, walnuts, flax seed (linseed oil), perilla, chia, and hemp seed. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Gamma-Linolenic acid」の詳細全文を読む スポンサード リンク
|